Structural Brain Correlates of Human Sleep Oscillations

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Structural Brain Correlates of Human Sleep Oscillations

Highlights

  • Sleep EEG and brain structure independently demonstrate trait-like variability.
  • We test whether brain structure explains individual differences in sleep features.
  • Somatosensory cortex and hippocampus structure explained differences in spindles.
  • Medial prefrontal and basal forebrain structure predicted differences in slow waves.
  • Brain structure is a factor accounting for individual differences in sleep features.

Abstract

Sleep is strongly conserved within species, yet marked and perplexing inter-individual differences in sleep physiology are observed. Combining EEG sleep recordings and high-resolution structural brain imaging, here we demonstrate that the morphology of the human brain offers one explanatory factor of such inter-individual variability. Gray matter volume in interoceptive and exteroceptive cortices correlated with the expression of slower NREM sleep spindle frequencies, supporting their proposed role in sleep protection against conscious perception. Conversely, and consistent with an involvement in declarative memory processing, gray matter volume in bilateral hippocampus was associated with faster NREM sleep spindle frequencies. In contrast to spindles, gray matter volume in the homeostatic sleep-regulating center of the basal forebrain/hypothalamus, together with the medial prefrontal cortex, accounted for individual differences in NREM slow wave oscillations. Together, such findings indicate that the qualitative and quantitative expression of human sleep physiology is significantly related to anatomically specific differences in macroscopic brain structure.

Keywords

Sleep spindles; Slow waves; Gray matter; VBM; EEG; NREM sleep

 

Original article on: http://www.sciencedirect.com/science/article/pii/S1053811913006587